Image processing All image processing was performed using Relion 2. Supporting information. S1 Fig. Cryomicrograph of HSV-1 virions. S2 Fig. Fourier shell correlation plot for the icosahedral reconstruction of HSV S3 Fig. Focussed classification to identify the portal-vertex in HSV S4 Fig. Fourier shell correlation plot for the C5 reconstruction of HSV S1 Data.
Fourier shell correlation data for the icosahedral reconstruction of HSV S2 Data. S3 Data. Fourier shell correlation data for the C5 reconstruction of HSV S1 Movie. Movie to show the structure of CATC proteins at the portal and penton vertices. CATC, capsid-associated tegument complex. S2 Movie. Movie to show the structure of the portal-vertex associated tegument protein. S3 Movie. Movie to show the structure of internal features at the portal-vertex. S4 Movie. Acknowledgments The authors thank Dr Kyle Dent of the electron bioimaging centre at Diamond Light Source for his expert support in collecting the data described herein.
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Methods Enzymol. Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf It may affect one or both eyes and causes:.
Anyone who suspects herpes keratitis should see a doctor. Without treatment, the infection can scar the eye, leading to cloudy vision, or even vision loss. Herpes is a mild skin condition caused by the herpes simplex virus.
It causes blister-like sores to appear anywhere on the body. The most commonly affected areas include around the mouth, the genitals, and buttocks. There is no cure for HSV, and people who have contracted the virus will usually experience breakouts from time to time. The sores usually clear up on their own, though people can help treat outbreaks using antiviral medicine, such as:.
These treatments, which are available as creams or pills from drug stores or on prescription, can shorten the duration of a herpes outbreak. To avoid transmitting herpes to other people, avoid skin-to-skin contact during flare-ups of symptoms, especially when the sores are open. When a person has genital herpes, they can reduce the risk of transmitting the virus by using a condom between outbreaks.
People with oral herpes can reduce the risk of transmission by avoiding kissing, sharing tableware, or performing oral sex during an outbreak. Antiviral medication is available for purchase online. Read the article in Spanish. What are some of the best home remedies for herpes? Keep reading to learn about which home remedies may be effective and the supporting research.
Many at-home herpes tests are available to purchase. Learn about how they work, their pros and cons, and four of the best at-home herpes tests…. Herpes can cause painful blisters and sores to the mouth and genitals. Learn about treatments and when to get tested here. Valacyclovir is a medication that can help to treat infections caused by the herpes virus.
Read on for more. Our 3D reconstruction of the portal-vertex also shows that one end of the viral genome extends outside the portal in the manner described for some bacteriophages but not previously seen in any eukaryote viruses.
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